Endocrine Abstracts

We have already reported that synthetic analogs of 3-iodothyronamine (T1AM), a naturally occurring thyroid hormone derivative, share a pleiotropic activity with the endogenous parent compound, including autophagic flux promotion (ATG), neuroprotection, and metabolic reprogramming. Our study aimed to determine whether the T1AM lead analog SG2 and its derivatives SG22 and SG23, developed as prodrugs of SG2, can protect human glioblastoma U87 MG cells from the toxic effects induc...

Microglial dysfunction is one of the hallmarks and leading causes of common neurodegenerative diseases (NDD), including Alzheimer’s disease (AD), Parkinson’s disease (AD), and amyotrophic lateral sclerosis (ALS). All these pathologies are characterized by aberrant aggregation of disease-causing proteins in the brain, which can directly activate microglia, trigger microglia-mediated neuroinflammation, and increase oxidative stress. The availability of cell-permeable i...

Please Development and preliminary characterization of a simple human thyroid organoid in vitro model for thyroid metabolism investigation For decades, in vitro studies of the thyroid have relied on thyroid-derived tumor cell lines, which are limited by their undifferentiated phenotype, lack of response to TSH, and chromosomal abnormalities. A viable alternative are monolayer (2D) cultures of primary thyrocytes isolated from histologically normal thyroid glan...